The .mde file extension is most commonly associated with the Microsoft Access database application. When Microsoft Access is used to compile database modules and remove editable source codes, the resulting database file is stored in MDE format. These files allow users to perform operations within the database without allowing them to make any changes to the database objects or code.
The .mde file extension is also used for Tonline database files and ArchiCAD educational version module files.
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If you have additional information about the MDE file format or software that uses files with the MDE suffix, please do get in touch - we would love hearing from you.