The .layout file extension is most commonly associated with Apple MainStage layout files. These files allow a user to customize the look and feel of the Apple MainStage interface, such as the layout of the interface and the color of the MainStage controls.
The .layout file extension is also used for Adobe Premiere Layout files.
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If you have additional information about the LAYOUT file format or software that uses files with the LAYOUT suffix, please do get in touch - we would love hearing from you.