The .nup file extension is most commonly used by the ESET Nod32 anti-virus software. Files with the .nup extension contain update information for the anti-virus application. These updates are installed by the software to maintain up-to-date virus definitions and anti-virus protection.
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If you have additional information about the NUP file format or software that uses files with the NUP suffix, please do get in touch - we would love hearing from you.